United against Barack Obama, Senate Republicans voted Tuesday night to kill the jobs package the president had spent weeks campaigning for across the country, a stinging loss at the hands of lawmakers opposed to stimulus-style spending and a tax increase on the very wealthy.

Forty-six Republicans joined with two Democrats to filibuster the $447 billion plan. Fifty Democrats had voted for it, but the vote was not final. The roll call was kept open to allow Sen. Jeanne Shaheen, D-N.H. to vote. The likely 51-48 eventual tally would be far short of the 60 votes needed to keep the bill alive in the 100-member Senate.

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Democrats Ben Nelson of Nebraska and Jon Tester of Montana — both up for re-election next year in states where Obama figures to lose — broke with their party on Tuesday night’s vote. Every Republican present opposed the plan.